Most senior member of a group
Most senior of two
Most senseless
Most sensible
Most sensitive
Most serene
Most serious
Most serious kind of flu
Most serious, as a felony
Most severe
Most shaggy / Hotel offering / Actress Goldie
Most shameful
Most sharp
Most sharply inclined
Most sheltered
Most shipshape
Most shoddy
most sick
Most sickly
Most significant
Most significant entitlement
Most significantly, in texting
Most silly
Most silverware, actually
Most similar to the Sahara
Most simple
most simple not hard at all
Most sincere
Most sinuous
Most skilled
Most skillful
Most skittish
Most sky-colored
Most slapstick
most sleazy
Most sleepy
Most slim
Most slippery
Most slow-witted
Most slush pile responses
Most small-minded
Most smart
Most smooth and lustrous
Most smooth and stylish
Most smooth, as peanut butter
Most snarky
Most sneaky
most snobbish
Most snug
most soaked
Most Soc. Sec. beneficiaries
Most Soc. Sec. recipients
Most socially conscious
Most soiled
Most soldiers
most solid
Most sophisticated
Most sordid
Most sore
MOST SORROWFUL
Most sought-after party guests
Most sound
Most sound, mentally
Most sour
Most sour-tasting
Most spacious
Most spam
Most spare
Most sparse
Most sparsely furnished
Most sparsely populated Eur. country
Most sparsely populated European country
Most Spartan
Most spick-and-span
Most spicy
Most spiders have eight
Most spiffy
Most spine-tingling
most spiteful
Most sporting
Most sports fans
Most spotless
most sprightly
Most spruce
Most stable
Most stale
Most stale and moldy
Most standoffish
Most starfish have five
Most state-of-the-art
Most steaks
most stern
Most sticky, as a sweet treat
Most stiffly proper
Most stomach-turning
Most straight, as wheels
Most strange
Most strapping
Most stretched
Most strict
Most strongly built
Most stuck-up
Most student drivers
Most Stuf cookie
Most stylish
Most subdued
most submissive
Most substantial
Most succinct
most sued mascot
Most sugary
most suitable
Most suitable for service
Most sunburned
Most Super Bowl M.V.P.s
Most supple
Most surly
Most susceptible to burning
Most susceptible to sunburn
Most suspenseful
Most suspicious person born in early April?
Most swanky
Most sweaters and jerseys
Most sweeping
Most sweet and kind
Most sycophantic
Most Syrians
Most tacky
Most tailor's chalk
Most tall and thin
Most tangy
Most Tangy drink
Most tardy
Most tart
Most tasteless
Most tastelessly showy
Most taxed person in April?
Most taxis
Most teachers
most tearful
Most teensy
Most temperamental
most tender
Most tender to the touch
Most tense
Most terrible
Most terrific
Most terse
Most texts
Most thick, as fog
Most thickheaded
Most thickset
Most thin, as fabric
Most thinly scattered
Most thirsty
Most thoughtful
Most Three Stooges films
Most tic-tac-toe outcomes
Most ticked off
Most ticklish
Most tidy
Most tightly drawn
Most tightly packed
Most Times Square signage
most timid
Most tiny
Most tip jar bills
Most tired
Most tiresome
Most tiring
most tiring back breaking
Most titillating
Most to one side
Most to the point
Most toasty
Most together
Most together, mentally
Most toilet seats
Most towering
Most translucent
Most transparent
Most treacherous for driving, maybe
Most treasured
Most trick-or-treaters
Most trifling
Most trite
Most trivial
Most truckers
Most trusted
Most trusted knight of King Arthur
Most trustworthy
Most Tunisians
Most Turks and Egyptians
Most turns off the tpk.
Most TV "operas"
Most TV Land programming
Most U.S. states have one that isn't in English
Most uncomfortable
Most uncommon
Most uncomplimentary, as a remark
Most unconvincing
Most uncool
Most unctuous
Most underhanded
Most undisciplined and unruly
Most unearthly
Most unemotional
Most unexpected
Most unfavorable
Most unfavorably
most unfeeling as a stare
Most unflappable
Most uninspired
Most unique
Most univ. applicants
Most unkempt
Most unkind
Most unlike a 35-Down
Most unlikely, as a story
Most unoriginal
Most unpleasant
Most unruffled
Most unsatisfactory
Most unsullied
Most unsympathetic
Most unusual
Most unwavering
Most unwell
Most up in the air
most up to date
Most up to the job
Most up to the task
Most up-to-date
Most upbeat
Most updated
Most upset
Most upstanding or dependable
Most uptight
Most urgent
Most US college students these days
Most vague
Most valiant
Most Valuable Player and others
Most valuable player awards?
Most valuable Scrabble square, reduced?
Most valuable, possibly
Most vending machine cash
Most venerable
Most viable option
Most vicious